ea0063p261 | Pituitary and Neuroendocrinology 1 | ECE2019
Peverelli Erika
, Treppiedi Donatella
, Giardino Elena
, Catalano Rosa
, Mangili Federica
, Vercesi Pietro
, Locatelli Marco
, Spada Anna
, Arosio Maura
, Mantovani Giovanna
Cushings Disease (CD) is a rare condition characterized by an overproduction of ACTH by an ACTH-secreting pituitary tumor, resulting in excess of cortisol release by the adrenal glands. Pasireotide is the pituitary-targeted drug approved to treat adult patients. Its mechanism of action seems to rely on the preferential binding to the highly expressed somatostatin receptor in corticotroph tumors, SST5. Recently, somatic mutations in the deubiquitinase USP8 gene h...